42 lines
1.3 KiB
Markdown
42 lines
1.3 KiB
Markdown
---
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name: experiment-design
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description: "Design rigorous experiments following best practices. Use when: (1) Planning research studies, (2) Grant proposal development, (3) Pre-registration, (4) Ensuring internal validity, (5) Meeting NIH rigor standards."
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allowed-tools: Read, Write
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version: 1.0.0
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---
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# Experiment Design Skill
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## Purpose
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Design methodologically rigorous experiments with appropriate controls and randomization.
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## Key Design Elements
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**1. Research Question**: Clear, testable hypothesis
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**2. Study Design**: RCT, quasi-experimental, observational
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**3. Sample Size**: Power analysis justified
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**4. Randomization**: Method specified
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**5. Blinding**: Who is blinded
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**6. Controls**: Appropriate comparison groups
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**7. Outcomes**: Primary and secondary clearly defined
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**8. Analysis Plan**: Pre-specified statistical approach
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## Common Designs
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**Between-Subjects**: Different participants per condition
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**Within-Subjects**: Same participants, repeated measures
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**Factorial**: Multiple factors (2x2, 2x3)
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**Crossover**: Participants receive all treatments
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**Stepped-Wedge**: Phased rollout
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## NIH Rigor Checklist
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- [ ] Scientific premise established
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- [ ] Rigorous design (appropriate controls)
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- [ ] Biological variables considered (SABV)
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- [ ] Authentication of key resources
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- [ ] Transparent reporting planned
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---
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**Version:** 1.0.0
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