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Zhongwei Li
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skills/venue-templates/assets/grants/nih_specific_aims.tex
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skills/venue-templates/assets/grants/nih_specific_aims.tex
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% NIH Specific Aims Page Template
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% THE MOST CRITICAL PAGE OF YOUR NIH PROPOSAL
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% 1 page maximum - strictly enforced
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% Last updated: 2024
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\documentclass[11pt,letterpaper]{article}
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% Formatting
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\usepackage[margin=0.5in]{geometry} % 0.5 inch minimum margins
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\usepackage{helvet} % Arial-like font
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\renewcommand{\familydefault}{\sfdefault}
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\usepackage{setspace}
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\usepackage{color}
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\usepackage{soul} % For highlighting (remove in final version)
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% Remove page numbers (optional)
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\pagestyle{empty}
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\begin{document}
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% Optional: Highlight template text to remind yourself to replace
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% Remove \hl{} and color in final version
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\definecolor{highlight}{RGB}{255,255,200}
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\sethlcolor{highlight}
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% ====================
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% SPECIFIC AIMS PAGE
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% ====================
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\begin{center}
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\textbf{\large Your Project Title Here: Concise and Descriptive}
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\end{center}
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\vspace{0.3cm}
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% OPENING PARAGRAPH: The Hook and Gap
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% 2-3 sentences establishing significance and the knowledge gap
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\textbf{[Disease/condition]} affects \textbf{[number]} people worldwide and results in \textbf{[burden: mortality, morbidity, cost]}. \textbf{[Current treatment/understanding]} has improved outcomes, but \textbf{[limitation/gap]} remains a critical barrier to \textbf{[desired outcome]}. Understanding \textbf{[specific mechanism/relationship]} is essential for \textbf{[future advance: therapy, prevention, diagnosis]}.
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\vspace{0.2cm}
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% LONG-TERM GOAL
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% 1 sentence on your overarching research vision
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Our \textbf{long-term goal} is to \textbf{[overarching vision: develop cure, understand mechanism, improve treatment]} for \textbf{[disease/population]}.
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\vspace{0.2cm}
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% OBJECTIVE AND CENTRAL HYPOTHESIS
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% 1-2 sentences on what THIS proposal will accomplish
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The \textbf{objective} of this proposal is to \textbf{[specific objective for this project]}. Our \textbf{central hypothesis} is that \textbf{[clearly stated, testable hypothesis]}.
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\vspace{0.2cm}
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% RATIONALE
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% 2-3 sentences explaining WHY you expect success (preliminary data!)
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This hypothesis is based on our \textbf{preliminary data} showing that \textbf{[key preliminary finding 1]} and \textbf{[key preliminary finding 2]}. These findings suggest that \textbf{[mechanistic explanation or expected outcome]}.
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\vspace{0.2cm}
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% TRANSITION TO AIMS
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% 1 sentence introducing the specific aims
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To test this hypothesis and achieve our objective, we will pursue the following \textbf{Specific Aims}:
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\vspace{0.3cm}
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% ====================
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% SPECIFIC AIM 1
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% ====================
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\noindent\textbf{Specific Aim 1: [Concise, active verb title describing what you'll do].}
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\textit{Working Hypothesis:} \hl{State testable hypothesis for this aim.}
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We will \textbf{[approach/method]} to determine \textbf{[what you'll learn]}. We will use \textbf{[model system/approach]} to test whether \textbf{[specific prediction]}.
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\textbf{Expected Outcome:} We expect to find that \textbf{[predicted result]}. This outcome will demonstrate that \textbf{[significance of finding]} and will be \textbf{[positive/negative/innovative/transformative]} because \textbf{[why it matters]}.
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\vspace{0.3cm}
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% ====================
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% SPECIFIC AIM 2
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% ====================
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\noindent\textbf{Specific Aim 2: [Title of second aim].}
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\textit{Working Hypothesis:} \hl{Testable hypothesis for Aim 2.}
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Building on Aim 1, we will \textbf{[approach]} to \textbf{[objective]}. We will employ \textbf{[method/technique]} in \textbf{[model/population]} to test the hypothesis that \textbf{[specific prediction]}.
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\textbf{Expected Outcome:} These studies will reveal \textbf{[predicted finding]}. This is significant because \textbf{[impact on field/understanding]}.
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\vspace{0.3cm}
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% ====================
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% SPECIFIC AIM 3 (OPTIONAL)
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% ====================
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\noindent\textbf{Specific Aim 3: [Title of third aim].}
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\textit{Working Hypothesis:} \hl{Testable hypothesis for Aim 3.}
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To translate findings from Aims 1-2, we will \textbf{[approach]} to determine \textbf{[translational objective]}. We will \textbf{[method]} using \textbf{[clinically relevant model/patient samples]} to test whether \textbf{[translational prediction]}.
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\textbf{Expected Outcome:} We anticipate that \textbf{[result]}, which will provide \textbf{[proof-of-concept/validation/mechanism]} for \textbf{[therapeutic/diagnostic/preventive strategy]}.
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\vspace{0.3cm}
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% ====================
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% PAYOFF PARAGRAPH
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% ====================
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% 2-3 sentences on IMPACT, INNOVATION, and FUTURE DIRECTIONS
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\textbf{Impact and Innovation:} This project is \textbf{innovative} because it \textbf{[novel aspect: new concept, method, approach, application]}. The proposed research is \textbf{significant} because it will \textbf{[advance the field by...]} and will ultimately lead to \textbf{[long-term impact: improved treatment, new therapeutic target, diagnostic tool]}. Upon completion of these studies, we will be positioned to \textbf{[next steps: clinical trial, mechanistic studies, therapeutic development]}.
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\vspace{0.5cm}
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% ====================
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% ALTERNATIVE STRUCTURE (if preferred)
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% ====================
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% Some successful Specific Aims pages use this alternative structure:
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% - Open with hook (same as above)
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% - State long-term goal and objective (same)
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% - Present central hypothesis with 2-3 supporting pieces of preliminary data
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% - Then state: "We will test this hypothesis through three Specific Aims:"
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% - List aims more concisely (1-2 sentences each, plus expected outcome)
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% - Conclude with payoff paragraph emphasizing innovation, significance, impact
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\end{document}
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% ====================
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% TIPS FOR WRITING SPECIFIC AIMS
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% ====================
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% 1. START WITH A HOOK
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% - Open with the big picture: disease burden, societal cost, mortality
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% - Use compelling statistics
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% - Make it clear why anyone should care
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% 2. IDENTIFY THE GAP
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% - What's currently known?
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% - What's the critical barrier or unknown?
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% - Why does it matter?
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% 3. STATE YOUR HYPOTHESIS EXPLICITLY
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% - Clear, testable hypothesis
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% - Not "We hypothesize that we will study..." (that's not a hypothesis!)
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% - "We hypothesize that [mechanism] causes [outcome]"
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% 4. SHOW PRELIMINARY DATA
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% - Demonstrate feasibility
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% - Prove you're not starting from scratch
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% - Build confidence in your approach
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% 5. THREE AIMS (TYPICALLY)
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% - Can be 2 or 4, but 3 is most common
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% - Aims should be related but somewhat independent
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% - Failure of one aim shouldn't sink the whole project
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% - Aims can build on each other (Aim 1 → Aim 2 → Aim 3)
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% 6. EACH AIM SHOULD HAVE:
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% - Clear title (active verb)
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% - Working hypothesis
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% - Approach/method
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% - Expected outcome
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% - Significance/impact
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% 7. END WITH PAYOFF
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% - Innovation: What's new/different?
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% - Significance: Why does it matter?
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% - Impact: What will change?
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% - Future: Where does this lead?
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% 8. COMMON MISTAKES TO AVOID
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% - Too much background (this is not a mini-review)
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% - Vague hypotheses or objectives
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% - Missing expected outcomes
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% - No preliminary data mentioned
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% - Too ambitious (can't do it all in 5 years)
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% - Not addressing innovation and significance
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% - Poor logical flow between aims
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% - Exceeding 1 page (auto-reject!)
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% 9. FORMATTING RULES (STRICTLY ENFORCED)
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% - 1 page maximum (including all text, no figures typically)
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% - Arial 11pt minimum (or equivalent)
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% - 0.5 inch margins minimum
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% - Any spacing (single, 1.5, double acceptable)
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% - No smaller fonts allowed (even for superscripts/subscripts)
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% 10. REVISION STRATEGY
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% - Write, get feedback, revise 10+ times
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% - Every word must earn its place
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% - Test on non-specialist colleagues
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% - Read aloud to check flow
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% - Have it reviewed by successful R01 holders
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% - Mock study section review
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% ====================
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% EXAMPLES OF STRONG OPENING SENTENCES
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% ====================
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% DISEASE BURDEN APPROACH:
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% "Alzheimer's disease (AD) affects 6.7 million Americans and will cost $345 billion in 2023,
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% yet no disease-modifying therapies exist."
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% MECHANISTIC GAP APPROACH:
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% "Despite decades of research, the molecular mechanisms driving metastasis remain poorly understood,
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% limiting our ability to develop effective therapies for the 90% of cancer deaths caused by metastatic disease."
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% TRANSLATIONAL APPROACH:
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% "Current immunotherapies fail in 70% of patients with melanoma, largely because we cannot predict
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% who will respond, highlighting an urgent need for biomarkers of treatment response."
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% ====================
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% REMEMBER
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% ====================
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% The Specific Aims page is often the ONLY page reviewers read carefully before
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% forming their initial opinion. A weak Specific Aims page can doom an otherwise
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% excellent proposal. Invest the time to make it compelling, clear, and concise.
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% Get feedback from:
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% - Successful R01 awardees in your field
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% - Grant writing office at your institution
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% - Colleagues who've served on NIH study sections
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% - Non-specialists (if they can't understand it, reviewers may struggle too)
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375
skills/venue-templates/assets/grants/nsf_proposal_template.tex
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skills/venue-templates/assets/grants/nsf_proposal_template.tex
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% NSF Research Proposal Template
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% For NSF Standard Grant Proposals
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% Last updated: 2024
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% Based on NSF PAPPG (Proposal & Award Policies & Procedures Guide)
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\documentclass[11pt,letterpaper]{article}
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% Required formatting
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\usepackage[margin=1in]{geometry} % 1 inch margins required
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\usepackage{times} % Times Roman font (11pt minimum)
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\usepackage{graphicx}
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\usepackage{amsmath}
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\usepackage{amssymb}
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\usepackage{cite}
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\usepackage{hyperref}
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% Single spacing (NSF allows single spacing)
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\usepackage{setspace}
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\singlespacing
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% Page numbers
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\usepackage{fancyhdr}
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\pagestyle{fancy}
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\fancyhf{}
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\rhead{\thepage}
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\renewcommand{\headrulewidth}{0pt}
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\begin{document}
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% ====================
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% PROJECT SUMMARY (1 page maximum)
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% ====================
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\section*{Project Summary}
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\subsection*{Overview}
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Provide a concise 1-2 paragraph description of the proposed research. This should be understandable to a scientifically literate reader who is not a specialist in your field.
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\subsection*{Intellectual Merit}
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Describe how the project advances knowledge within its field and across different fields. Address:
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\begin{itemize}
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\item How the project advances understanding in the field
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\item Innovative aspects of the research
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\item Qualifications of the research team
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\item Adequacy of resources
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\end{itemize}
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\subsection*{Broader Impacts}
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Describe the potential benefits to society and contributions to desired societal outcomes. Address one or more of the following:
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\begin{itemize}
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\item Advancing discovery and understanding while promoting teaching and learning
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\item Broadening participation of underrepresented groups in STEM
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\item Disseminating broadly to enhance scientific and technological understanding
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\item Benefits to society (economic development, health, quality of life, national security, etc.)
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\item Developing the scientific workforce and enhancing research infrastructure
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\end{itemize}
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\newpage
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% ====================
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% PROJECT DESCRIPTION (15 pages maximum)
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% ====================
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\section*{Project Description}
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\section{Introduction and Background}
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\subsection{Current State of Knowledge}
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Provide context for your proposed research. Review relevant literature and establish what is currently known in the field.
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\subsection{Knowledge Gap}
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Clearly identify the gap in current knowledge or understanding that your project will address. Explain why this gap is significant.
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\subsection{Preliminary Work and Feasibility}
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Describe any preliminary work that demonstrates the feasibility of your approach. Highlight your team's qualifications and prior accomplishments.
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\section{Research Objectives and Hypotheses}
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\subsection{Overall Goal}
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State the overarching long-term goal of your research program.
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\subsection{Specific Objectives}
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List 2-4 specific, measurable objectives for this project:
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\begin{enumerate}
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\item \textbf{Objective 1:} Clearly stated objective
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\item \textbf{Objective 2:} Second objective
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\item \textbf{Objective 3:} Third objective
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\end{enumerate}
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\subsection{Hypotheses}
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State your testable hypotheses explicitly.
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\section{Research Plan}
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\subsection{Objective 1: [Title]}
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\subsubsection{Rationale}
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Explain why this objective is important and how it addresses the knowledge gap.
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\subsubsection{Approach and Methods}
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Describe in detail how you will accomplish this objective. Include:
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\begin{itemize}
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\item Experimental design or computational approach
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\item Methods and procedures
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\item Data collection and analysis
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\item Controls and validation
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\end{itemize}
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\subsubsection{Expected Outcomes}
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Describe what results you expect and how they will advance the field.
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\subsubsection{Potential Challenges and Alternatives}
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Identify potential obstacles and describe alternative approaches.
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\subsection{Objective 2: [Title]}
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[Repeat same structure as Objective 1]
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\subsection{Objective 3: [Title]}
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[Repeat same structure as Objective 1]
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\section{Timeline and Milestones}
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Provide a detailed timeline showing when each objective will be addressed:
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\begin{center}
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\begin{tabular}{|l|p{3cm}|p{3cm}|p{3cm}|}
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\hline
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\textbf{Activity} & \textbf{Year 1} & \textbf{Year 2} & \textbf{Year 3} \\
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\hline
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Objective 1 activities & Months 1-6: ... & & \\
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||||
\hline
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||||
Objective 2 activities & Months 7-12: ... & Months 13-18: ... & \\
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||||
\hline
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||||
Objective 3 activities & & Months 19-24: ... & Months 25-36: ... \\
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\hline
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Publications & & Submit paper 1 & Submit papers 2-3 \\
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\hline
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\end{tabular}
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\end{center}
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\section{Broader Impacts}
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\textit{Note: Broader Impacts must be substantive, not perfunctory. Integrate throughout proposal.}
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\subsection{Educational Activities}
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Describe specific educational activities integrated with the research:
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\begin{itemize}
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||||
\item Curriculum development
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||||
\item Training of graduate and undergraduate students
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||||
\item K-12 outreach programs
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\item Public science communication
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||||
\end{itemize}
|
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|
||||
\subsection{Broadening Participation}
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Describe concrete efforts to broaden participation of underrepresented groups:
|
||||
\begin{itemize}
|
||||
\item Recruitment strategies
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||||
\item Mentoring programs
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||||
\item Partnerships with minority-serving institutions
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\item Measurable outcomes
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||||
\end{itemize}
|
||||
|
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\subsection{Dissemination and Outreach}
|
||||
Describe plans for broad dissemination:
|
||||
\begin{itemize}
|
||||
\item Open-access publications
|
||||
\item Data and code sharing (repositories, licenses)
|
||||
\item Conference presentations and workshops
|
||||
\item Public engagement activities
|
||||
\end{itemize}
|
||||
|
||||
\subsection{Societal Benefits}
|
||||
Explain potential benefits to society:
|
||||
\begin{itemize}
|
||||
\item Economic development
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||||
\item Health and quality of life improvements
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||||
\item Environmental sustainability
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||||
\item National security (if applicable)
|
||||
\end{itemize}
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|
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\subsection{Assessment of Broader Impacts}
|
||||
Describe how you will measure the success of broader impacts activities. Include specific, measurable outcomes.
|
||||
|
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\section{Results from Prior NSF Support}
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\textit{Required if PI or co-PI has received NSF funding in the past 5 years}
|
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|
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\subsection{Award Title and Number}
|
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Award Number: NSF-XXXXX, Amount: \$XXX,XXX, Period: MM/YY - MM/YY
|
||||
|
||||
\subsection{Intellectual Merit}
|
||||
Summarize research accomplishments and findings from prior award.
|
||||
|
||||
\subsection{Broader Impacts}
|
||||
Describe broader impacts activities and outcomes from prior award.
|
||||
|
||||
\subsection{Publications}
|
||||
List publications resulting from prior NSF support (up to 5 most significant):
|
||||
\begin{enumerate}
|
||||
\item Author, A.A., et al. (Year). Title. \textit{Journal}, vol(issue), pages.
|
||||
\end{enumerate}
|
||||
|
||||
\newpage
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||||
|
||||
% ====================
|
||||
% REFERENCES CITED (No page limit)
|
||||
% ====================
|
||||
|
||||
\section*{References Cited}
|
||||
|
||||
\begin{thebibliography}{99}
|
||||
|
||||
\bibitem{ref1}
|
||||
Author, A.A., \& Author, B.B. (2023). Article title. \textit{Journal Name}, \textit{45}(3), 123-145.
|
||||
|
||||
\bibitem{ref2}
|
||||
Author, C.C., Author, D.D., \& Author, E.E. (2022). Book title. Publisher.
|
||||
|
||||
\bibitem{ref3}
|
||||
Author, F.F., et al. (2021). Another article. \textit{Nature}, \textit{590}, 234-238.
|
||||
|
||||
% Add more references as needed
|
||||
|
||||
\end{thebibliography}
|
||||
|
||||
\newpage
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||||
|
||||
% ====================
|
||||
% BUDGET JUSTIFICATION (3-5 pages typical)
|
||||
% Note: Budget is submitted separately in NSF's systems
|
||||
% This justifies the budget requests
|
||||
% ====================
|
||||
|
||||
\section*{Budget Justification}
|
||||
|
||||
\subsection*{A. Senior Personnel}
|
||||
\textbf{PI Name (X\% academic year, Y summer months):} Justify percent effort and role in project. Summer salary calculated as X/9 of academic year salary.
|
||||
|
||||
\textbf{Co-PI Name (X\% academic year):} Justify role and effort.
|
||||
|
||||
\subsection*{B. Other Personnel}
|
||||
\textbf{Postdoctoral Researcher (1.0 FTE, Years 1-3):} Justify need for postdoc, qualifications required, and role in project. Salary: \$XX,XXX/year.
|
||||
|
||||
\textbf{Graduate Student (2 students, Years 1-3):} Justify need, training opportunities, and project contributions. Stipend: \$XX,XXX/year per student.
|
||||
|
||||
\textbf{Undergraduate Researchers (2 students/year):} Describe research training opportunities. Hourly wage: \$XX/hour.
|
||||
|
||||
\subsection*{C. Fringe Benefits}
|
||||
List fringe benefit rates for each personnel category as determined by institution.
|
||||
|
||||
\subsection*{D. Equipment (\$5,000+)}
|
||||
\textbf{Instrument Name (\$XX,XXX):} Justify need, explain why existing equipment inadequate, describe how it enables proposed research.
|
||||
|
||||
\subsection*{E. Travel}
|
||||
\textbf{Domestic Conference Travel (\$X,XXX/year):} Justify conference attendance for dissemination (1-2 conferences/year for PI and students).
|
||||
|
||||
\textbf{Field Work Travel (\$X,XXX):} If applicable, justify field site visits.
|
||||
|
||||
\subsection*{F. Participant Support Costs}
|
||||
\textit{If hosting workshop, summer program, etc.}
|
||||
|
||||
Stipends, travel, and per diem for XX participants attending [workshop/program name].
|
||||
|
||||
\subsection*{G. Other Direct Costs}
|
||||
\textbf{Materials and Supplies (\$X,XXX/year):} Itemize major categories (e.g., chemicals, consumables, software licenses).
|
||||
|
||||
\textbf{Publication Costs (\$X,XXX):} Budget for open-access publication fees (estimate X papers @ \$X,XXX each).
|
||||
|
||||
\textbf{Subaward to Partner Institution (\$XX,XXX):} Justify collaboration and subaward amount.
|
||||
|
||||
\textbf{Other:} Justify any other costs.
|
||||
|
||||
\subsection*{H. Indirect Costs}
|
||||
Calculated at XX\% of Modified Total Direct Costs (institution's negotiated rate).
|
||||
|
||||
\newpage
|
||||
|
||||
% ====================
|
||||
% DATA MANAGEMENT PLAN (2 pages maximum)
|
||||
% ====================
|
||||
|
||||
\section*{Data Management Plan}
|
||||
|
||||
\subsection*{Types of Data}
|
||||
Describe the types of data to be generated by the project:
|
||||
\begin{itemize}
|
||||
\item Experimental data (e.g., measurements, observations)
|
||||
\item Computational data (e.g., simulation results, models)
|
||||
\item Metadata describing data collection and processing
|
||||
\end{itemize}
|
||||
|
||||
\subsection*{Data and Metadata Standards}
|
||||
Describe standards to be used for data format and metadata:
|
||||
\begin{itemize}
|
||||
\item File formats (e.g., HDF5, NetCDF, CSV)
|
||||
\item Metadata standards (e.g., Dublin Core, domain-specific standards)
|
||||
\item Documentation of data collection and processing
|
||||
\end{itemize}
|
||||
|
||||
\subsection*{Policies for Access and Sharing}
|
||||
Describe how data will be made accessible:
|
||||
\begin{itemize}
|
||||
\item Repository for data deposition (e.g., Dryad, Zenodo, domain-specific archive)
|
||||
\item Timeline for public release (immediately upon publication, or within X months)
|
||||
\item Access restrictions (if any) and justification
|
||||
\item Embargo periods (if applicable)
|
||||
\end{itemize}
|
||||
|
||||
\subsection*{Policies for Re-use, Redistribution}
|
||||
Describe terms for re-use:
|
||||
\begin{itemize}
|
||||
\item Licensing (e.g., CC0, CC-BY, specific data use agreement)
|
||||
\item Attribution requirements
|
||||
\item Restrictions on commercial use (if any)
|
||||
\end{itemize}
|
||||
|
||||
\subsection*{Plans for Archiving and Preservation}
|
||||
Describe long-term preservation strategy:
|
||||
\begin{itemize}
|
||||
\item Repository selection (long-term, stable repositories)
|
||||
\item Preservation period (minimum 3-5 years post-project)
|
||||
\item Data formats for long-term preservation
|
||||
\item Institutional commitments
|
||||
\end{itemize}
|
||||
|
||||
\subsection*{Roles and Responsibilities}
|
||||
Identify who is responsible for data management implementation.
|
||||
|
||||
\end{document}
|
||||
|
||||
% ====================
|
||||
% ADDITIONAL DOCUMENTS (submitted separately in NSF system)
|
||||
% ====================
|
||||
|
||||
% 1. BIOGRAPHICAL SKETCH (3 pages per person)
|
||||
% - Use NSF-approved format (SciENcv or NSF template)
|
||||
% - Professional preparation
|
||||
% - Appointments
|
||||
% - Products (up to 5 most relevant, up to 5 other significant)
|
||||
% - Synergistic activities
|
||||
|
||||
% 2. CURRENT AND PENDING SUPPORT
|
||||
% - All current and pending support for all senior personnel
|
||||
% - Use NSF format
|
||||
% - Check for overlap with proposed project
|
||||
|
||||
% 3. FACILITIES, EQUIPMENT, AND OTHER RESOURCES
|
||||
% - Describe available facilities and equipment
|
||||
% - Computational resources
|
||||
% - Laboratory space
|
||||
% - Other resources supporting the project
|
||||
|
||||
% ====================
|
||||
% FORMATTING CHECKLIST
|
||||
% ====================
|
||||
|
||||
% ☐ Margins: 1 inch on all sides
|
||||
% ☐ Font: Times Roman 11pt or larger (or equivalent)
|
||||
% ☐ Line spacing: Single spacing acceptable
|
||||
% ☐ Project Summary: 1 page, includes Overview, Intellectual Merit, Broader Impacts
|
||||
% ☐ Project Description: 15 pages maximum
|
||||
% ☐ References Cited: No page limit, consistent formatting
|
||||
% ☐ Biographical Sketches: 3 pages per person, NSF-approved format
|
||||
% ☐ Budget Justification: Detailed and reasonable
|
||||
% ☐ Data Management Plan: 2 pages maximum
|
||||
% ☐ Current & Pending: Complete and accurate
|
||||
% ☐ Facilities: Adequate resources described
|
||||
% ☐ Broader Impacts: Substantive and integrated throughout
|
||||
% ☐ All required sections included
|
||||
|
||||
% ====================
|
||||
% SUBMISSION NOTES
|
||||
% ====================
|
||||
|
||||
% 1. Submit through Research.gov or Grants.gov
|
||||
% 2. Follow your institution's internal deadlines (usually 3-5 days before NSF deadline)
|
||||
% 3. Obtain institutional approval before submission
|
||||
% 4. Ensure all senior personnel have NSF IDs
|
||||
% 5. Budget prepared in NSF's system (separate from this document)
|
||||
% 6. Check program-specific requirements (may differ from standard grant)
|
||||
% 7. Contact Program Officer for guidance (encouraged but not required)
|
||||
|
||||
Reference in New Issue
Block a user