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+# Hypothesis Generation Report - Formatting Quick Reference
+
+## Overview
+
+This guide provides quick reference for using the hypothesis generation LaTeX template and style package. For complete documentation, see `SKILL.md`.
+
+## Quick Start
+
+```latex
+% !TEX program = xelatex
+\documentclass[11pt,letterpaper]{article}
+\usepackage{hypothesis_generation}
+\usepackage{natbib}
+
+\title{Your Phenomenon Name}
+\begin{document}
+\maketitle
+% Your content
+\end{document}
+```
+
+**Compilation:** Use XeLaTeX or LuaLaTeX for best results
+```bash
+xelatex your_document.tex
+bibtex your_document
+xelatex your_document.tex
+xelatex your_document.tex
+```
+
+## Color Scheme Reference
+
+### Hypothesis Colors
+- **Hypothesis 1**: Deep Blue (RGB: 0, 102, 153) - Use for first hypothesis
+- **Hypothesis 2**: Forest Green (RGB: 0, 128, 96) - Use for second hypothesis
+- **Hypothesis 3**: Royal Purple (RGB: 102, 51, 153) - Use for third hypothesis
+- **Hypothesis 4**: Teal (RGB: 0, 128, 128) - Use for fourth hypothesis (if needed)
+- **Hypothesis 5**: Burnt Orange (RGB: 204, 85, 0) - Use for fifth hypothesis (if needed)
+
+### Utility Colors
+- **Predictions**: Amber (RGB: 255, 191, 0) - For testable predictions
+- **Evidence**: Light Blue (RGB: 102, 178, 204) - For supporting evidence
+- **Comparisons**: Steel Gray (RGB: 108, 117, 125) - For critical comparisons
+- **Limitations**: Coral Red (RGB: 220, 53, 69) - For limitations/challenges
+
+## Custom Box Environments
+
+### 1. Executive Summary Box
+
+```latex
+\begin{summarybox}[Executive Summary]
+  Content here
+\end{summarybox}
+```
+
+**Use for:** High-level overview at the beginning of the document
+
+---
+
+### 2. Hypothesis Boxes (5 variants)
+
+```latex
+\begin{hypothesisbox1}[Hypothesis 1: Title]
+  \textbf{Mechanistic Explanation:}
+  [2-3 paragraphs explaining HOW and WHY]
+  
+  \textbf{Key Supporting Evidence:}
+  \begin{itemize}
+    \item Evidence point 1 \citep{ref1}
+    \item Evidence point 2 \citep{ref2}
+  \end{itemize}
+  
+  \textbf{Core Assumptions:}
+  \begin{enumerate}
+    \item Assumption 1
+    \item Assumption 2
+  \end{enumerate}
+\end{hypothesisbox1}
+```
+
+**Available boxes:** `hypothesisbox1`, `hypothesisbox2`, `hypothesisbox3`, `hypothesisbox4`, `hypothesisbox5`
+
+**Use for:** Presenting each competing hypothesis with its mechanism, evidence, and assumptions
+
+**Best practices for 4-page main text:**
+- Keep mechanistic explanations to 1-2 brief paragraphs only (6-10 sentences max)
+- Include 2-3 most essential evidence points with citations
+- List 1-2 most critical assumptions
+- Ensure each hypothesis is genuinely distinct
+- All detailed explanations go to Appendix A
+- **Use `\newpage` before each hypothesis box to prevent overflow**
+- Each complete hypothesis box should be ≤0.6 pages
+
+---
+
+### 3. Prediction Box
+
+```latex
+\begin{predictionbox}[Predictions: Hypothesis 1]
+  \textbf{Prediction 1.1:} [Specific prediction]
+  \begin{itemize}
+    \item \textbf{Conditions:} When/where this applies
+    \item \textbf{Expected Outcome:} Specific measurable result
+    \item \textbf{Falsification:} What would disprove it
+  \end{itemize}
+\end{predictionbox}
+```
+
+**Use for:** Testable predictions derived from each hypothesis
+
+**Best practices for 4-page main text:**
+- Make predictions specific and quantitative when possible
+- Clearly state conditions under which prediction should hold
+- Always specify falsification criteria
+- Include only 1-2 most critical predictions per hypothesis in main text
+- Additional predictions go to appendices
+
+---
+
+### 4. Evidence Box
+
+```latex
+\begin{evidencebox}[Supporting Evidence]
+  Content discussing supporting evidence
+\end{evidencebox}
+```
+
+**Use for:** Highlighting key supporting evidence or literature synthesis
+
+**Best practices:**
+- Use sparingly in main text (detailed evidence goes in Appendix A)
+- Include citations for all evidence
+- Focus on most compelling evidence
+
+---
+
+### 5. Comparison Box
+
+```latex
+\begin{comparisonbox}[H1 vs. H2: Key Distinction]
+  \textbf{Fundamental Difference:}
+  [Description of core difference]
+  
+  \textbf{Discriminating Experiment:}
+  [Description of experiment]
+  
+  \textbf{Outcome Interpretation:}
+  \begin{itemize}
+    \item \textbf{If [Result A]:} H1 supported
+    \item \textbf{If [Result B]:} H2 supported
+  \end{itemize}
+\end{comparisonbox}
+```
+
+**Use for:** Explaining how to distinguish between competing hypotheses
+
+**Best practices:**
+- Focus on fundamental mechanistic differences
+- Propose clear, feasible discriminating experiments
+- Specify concrete outcome interpretations
+- Create comparisons for all major hypothesis pairs
+
+---
+
+### 6. Limitation Box
+
+```latex
+\begin{limitationbox}[Limitations \& Challenges]
+  Discussion of limitations
+\end{limitationbox}
+```
+
+**Use for:** Highlighting important limitations or challenges
+
+**Best practices:**
+- Use when limitations are particularly important
+- Be honest about challenges
+- Suggest how limitations might be addressed
+
+---
+
+## Document Structure
+
+### Main Text (Maximum 4 Pages - Highly Concise)
+
+1. **Executive Summary** (0.5-1 page)
+   - Use `summarybox`
+   - Brief phenomenon overview
+   - List all hypotheses in 1 sentence each
+   - Recommended approach
+
+2. **Competing Hypotheses** (2-2.5 pages)
+   - Use `hypothesisbox1`, `hypothesisbox2`, etc.
+   - One box per hypothesis
+   - Brief mechanistic explanation (1-2 paragraphs) + essential evidence (2-3 points) + key assumptions (1-2)
+   - Target: 3-5 hypotheses
+   - Keep highly concise - details go to appendices
+
+3. **Testable Predictions** (0.5-1 page)
+   - Use `predictionbox` for each hypothesis
+   - 1-2 most critical predictions per hypothesis only
+   - Very brief - full predictions in appendices
+
+4. **Critical Comparisons** (0.5-1 page)
+   - Use `comparisonbox` for highest priority comparison only
+   - Show how to distinguish top hypotheses
+   - Additional comparisons in appendices
+
+**Main text total: Maximum 4 pages - be extremely selective about what goes here**
+
+### Appendices (Comprehensive, Detailed)
+
+**Appendix A: Comprehensive Literature Review**
+- Detailed background (extensive citations)
+- Current understanding
+- Evidence for each hypothesis (detailed)
+- Conflicting findings
+- Knowledge gaps
+- **Target: 40-60+ citations**
+
+**Appendix B: Detailed Experimental Designs**
+- Full protocols for each hypothesis
+- Methods, controls, sample sizes
+- Statistical approaches
+- Feasibility assessments
+- Timeline and resource requirements
+
+**Appendix C: Quality Assessment**
+- Detailed evaluation tables
+- Strengths and weaknesses analysis
+- Comparative scoring
+- Recommendations
+
+**Appendix D: Supplementary Evidence**
+- Analogous mechanisms
+- Preliminary data
+- Theoretical frameworks
+- Historical context
+
+**References**
+- **Target: 50+ total references**
+
+## Citation Best Practices
+
+### In Main Text
+- Cite 15-20 key papers
+- Use `\citep{author2023}` for parenthetical citations
+- Use `\citet{author2023}` for textual citations
+- Focus on most important/recent evidence
+
+### In Appendices
+- Cite 40-60+ papers total
+- Comprehensive coverage of relevant literature
+- Include reviews, primary research, theoretical papers
+- Cite every claim and piece of evidence
+
+### Citation Density Guidelines
+- Main hypothesis boxes: 2-3 citations per box (most essential only)
+- Main text total: 10-15 citations maximum (keep concise)
+- Appendix A literature sections: 8-15 citations per subsection
+- Experimental designs: 2-5 citations for methods/precedents
+- Quality assessments: Citations as needed for evaluation criteria
+- Total document: 50+ citations (vast majority in appendices)
+
+## Tables
+
+### Professional Table Formatting
+
+```latex
+\begin{hypotable}{Caption}
+\begin{tabular}{|l|l|l|}
+\hline
+\tableheadercolor
+\textcolor{white}{\textbf{Header 1}} & \textcolor{white}{\textbf{Header 2}} \\
+\hline
+Data row 1 & Data \\
+\hline
+\tablerowcolor  % Alternating gray background
+Data row 2 & Data \\
+\hline
+\end{tabular}
+\caption{Your caption}
+\end{hypotable}
+```
+
+**Best practices:**
+- Use `\tableheadercolor` for header rows
+- Alternate `\tablerowcolor` for tables >3 rows
+- Keep tables readable (not too wide)
+- Use for quality assessments, comparisons
+
+## Common Formatting Patterns
+
+### Hypothesis Section Pattern
+
+```latex
+% Use \newpage before hypothesis box to prevent overflow
+\newpage
+\subsection*{Hypothesis N: [Concise Title]}
+
+\begin{hypothesisboxN}[Hypothesis N: [Title]]
+
+\textbf{Mechanistic Explanation:}
+
+[1-2 brief paragraphs of explanation - 6-10 sentences max]
+
+\vspace{0.3cm}
+
+\textbf{Key Supporting Evidence:}
+\begin{itemize}
+  \item [Evidence 1] \citep{ref1}
+  \item [Evidence 2] \citep{ref2}
+  \item [Evidence 3] \citep{ref3}
+\end{itemize}
+
+\vspace{0.3cm}
+
+\textbf{Core Assumptions:}
+\begin{enumerate}
+  \item [Assumption 1]
+  \item [Assumption 2]
+\end{enumerate}
+
+\end{hypothesisboxN}
+
+\vspace{0.5cm}
+```
+
+**Note:** The `\newpage` before the hypothesis box ensures it starts on a fresh page, preventing overflow. This is especially important when boxes contain substantial content.
+
+### Prediction Section Pattern
+
+```latex
+\subsection*{Predictions from Hypothesis N}
+
+\begin{predictionbox}[Predictions: Hypothesis N]
+
+\textbf{Prediction N.1:} [Statement]
+\begin{itemize}
+  \item \textbf{Conditions:} [Conditions]
+  \item \textbf{Expected Outcome:} [Outcome]
+  \item \textbf{Falsification:} [Falsification]
+\end{itemize}
+
+\vspace{0.2cm}
+
+\textbf{Prediction N.2:} [Statement]
+[... continue ...]
+
+\end{predictionbox}
+```
+
+### Comparison Section Pattern
+
+```latex
+\subsection*{Distinguishing Hypothesis X vs. Hypothesis Y}
+
+\begin{comparisonbox}[HX vs. HY: Key Distinction]
+
+\textbf{Fundamental Difference:}
+
+[Description of core difference]
+
+\vspace{0.3cm}
+
+\textbf{Discriminating Experiment:}
+
+[Experiment description]
+
+\vspace{0.3cm}
+
+\textbf{Outcome Interpretation:}
+\begin{itemize}
+  \item \textbf{If [Result A]:} HX supported
+  \item \textbf{If [Result B]:} HY supported
+  \item \textbf{If [Result C]:} Both/neither supported
+\end{itemize}
+
+\end{comparisonbox}
+```
+
+## Spacing and Layout
+
+### Vertical Spacing
+- `\vspace{0.3cm}` - Between elements within boxes
+- `\vspace{0.5cm}` - Between major sections or boxes
+- `\vspace{1cm}` - After title, before main content
+
+### Page Breaks and Overflow Prevention
+
+**CRITICAL: Prevent Content Overflow**
+
+LaTeX boxes (tcolorbox environments) do not automatically break across pages. Content that exceeds the remaining page space will overflow and cause formatting issues. Follow these guidelines:
+
+1. **Strategic Page Breaks Before Long Boxes:**
+```latex
+\newpage  % Start on fresh page if box will be long
+\begin{hypothesisbox1}[Hypothesis 1: Title]
+  % Substantial content here
+\end{hypothesisbox1}
+```
+
+2. **Monitor Box Content Length:**
+   - Each hypothesis box should be ≤0.7 pages maximum
+   - If mechanistic explanation + evidence + assumptions exceeds ~0.6 pages, content is too long
+   - Solution: Move detailed content to appendices, keep only essentials in main text boxes
+
+3. **When to Use `\newpage`:**
+   - Before any hypothesis box with >3 subsections or >15 lines of content
+   - Before comparison boxes with extensive experimental descriptions
+   - Between major appendix sections
+   - If less than 0.6 pages remain on current page before starting a new box
+
+4. **Content Length Guidelines for Main Text:**
+   - Executive summary box: 0.5-0.8 pages max
+   - Each hypothesis box: 0.4-0.6 pages max
+   - Each prediction box: 0.3-0.5 pages max
+   - Each comparison box: 0.4-0.6 pages max
+
+5. **Breaking Up Long Content:**
+   ```latex
+   % GOOD: Concise main text with page break
+   \newpage
+   \begin{hypothesisbox1}[Hypothesis 1: Brief Title]
+   \textbf{Mechanistic Explanation:}
+   Brief overview in 1-2 paragraphs (6-10 sentences).
+   
+   \textbf{Key Supporting Evidence:}
+   \begin{itemize}
+     \item Evidence 1 \citep{ref1}
+     \item Evidence 2 \citep{ref2}
+   \end{itemize}
+   
+   \textbf{Core Assumptions:}
+   \begin{enumerate}
+     \item Assumption 1
+   \end{enumerate}
+   
+   See Appendix A for detailed mechanism and comprehensive evidence.
+   \end{hypothesisbox1}
+   ```
+
+   ```latex
+   % BAD: Overly long content that will overflow
+   \begin{hypothesisbox1}[Hypothesis 1]
+   \subsection{Very Long Section}
+   Multiple paragraphs...
+   \subsection{Another Long Section}
+   More paragraphs...
+   \subsection{Even More Content}
+   [Content continues beyond page boundary → OVERFLOW!]
+   \end{hypothesisbox1}
+   ```
+
+6. **Page Break Commands:**
+   - `\newpage` - Force new page (recommended before long boxes)
+   - `\clearpage` - Force new page and flush floats (use before appendices)
+
+### Section Spacing
+Already handled by style package, but you can adjust:
+```latex
+\vspace{0.5cm}  % Add extra space if needed
+```
+
+## Troubleshooting
+
+### Common Issues
+
+**Issue: "File hypothesis_generation.sty not found"**
+- Solution: Ensure the .sty file is in the same directory as your .tex file, or in your LaTeX path
+
+**Issue: Boxes don't have colors**
+- Solution: Compile with XeLaTeX or LuaLaTeX, not pdfLaTeX
+- Command: `xelatex yourfile.tex`
+
+**Issue: Citations show as [?]**
+- Solution: Run bibtex after first xelatex compilation
+```bash
+xelatex yourfile.tex
+bibtex yourfile
+xelatex yourfile.tex
+xelatex yourfile.tex
+```
+
+**Issue: Fonts not found**
+- Solution: Comment out font lines in the .sty file if custom fonts aren't installed
+- Lines to comment: `\setmainfont{...}` and `\setsansfont{...}`
+
+**Issue: Box titles overlap with content**
+- Solution: Add more vertical space with `\vspace{0.3cm}` after titles
+
+**Issue: Tables too wide**
+- Solution: Use `\small` or `\footnotesize` before tabular, or use `p{width}` column specs
+
+**Issue: Content overflowing off the page**
+- **Cause:** Boxes (tcolorbox environments) are too long to fit on remaining page space
+- **Solution 1:** Add `\newpage` before the box to start it on a fresh page
+- **Solution 2:** Reduce box content - move detailed information to appendices
+- **Solution 3:** Break content into multiple smaller boxes
+- **Prevention:** Keep each hypothesis box to 0.4-0.6 pages maximum; use `\newpage` liberally before boxes with substantial content
+
+**Issue: Main text exceeds 4 pages**
+- **Cause:** Boxes contain too much detailed information
+- **Solution:** Aggressively move content to appendices - main text boxes should contain only:
+  - Brief mechanistic overview (1-2 paragraphs)
+  - 2-3 key evidence bullets
+  - 1-2 core assumptions
+- All detailed explanations, additional evidence, and comprehensive discussions belong in Appendix A
+
+### Package Requirements
+
+Ensure these packages are installed:
+- `tcolorbox` (with `most` option)
+- `xcolor`
+- `fontspec` (for XeLaTeX/LuaLaTeX)
+- `fancyhdr`
+- `titlesec`
+- `enumitem`
+- `booktabs`
+- `natbib`
+
+Install missing packages:
+```bash
+# For TeX Live
+tlmgr install tcolorbox xcolor fontspec fancyhdr titlesec enumitem booktabs natbib
+
+# For MiKTeX (Windows)
+# Use MiKTeX Package Manager GUI
+```
+
+## Style Consistency Tips
+
+1. **Color Usage**
+   - Always use the same color for each hypothesis throughout the document
+   - H1 = blue, H2 = green, H3 = purple, etc.
+   - Don't mix colors for the same hypothesis
+
+2. **Box Usage**
+   - Main text: Hypothesis boxes, prediction boxes, comparison boxes
+   - Appendix: Can use evidence boxes, limitation boxes as needed
+   - Don't overuse boxes - reserve for key content
+
+3. **Citation Style**
+   - Consistent citation format throughout
+   - Use `\citep{}` for most citations
+   - Group multiple citations: `\citep{ref1, ref2, ref3}`
+
+4. **Hypothesis Numbering**
+   - Number hypotheses consistently (H1, H2, H3, etc.)
+   - Use same numbering in predictions (P1.1, P1.2 for H1)
+   - Use same numbering in comparisons (H1 vs. H2)
+
+5. **Language**
+   - Be precise and specific
+   - Avoid vague language ("may", "could", "possibly")
+   - Use active voice when possible
+   - Make predictions quantitative when feasible
+
+## Quick Checklist
+
+Before finalizing your document:
+
+- [ ] Title page has phenomenon name
+- [ ] **Main text is 4 pages maximum**
+- [ ] Executive summary is concise (0.5-1 page)
+- [ ] Each hypothesis in its own colored box
+- [ ] 3-5 hypotheses presented (not more)
+- [ ] Each hypothesis has brief mechanistic explanation (1-2 paragraphs)
+- [ ] Each hypothesis has 2-3 most essential evidence points with citations
+- [ ] Each hypothesis has 1-2 most critical assumptions
+- [ ] Predictions boxes with 1-2 key predictions per hypothesis
+- [ ] Priority comparison box in main text (others in appendix)
+- [ ] Priority experiments identified
+- [ ] **Page breaks (`\newpage`) used before long boxes to prevent overflow**
+- [ ] **No content overflows off page boundaries (check PDF carefully)**
+- [ ] **Each hypothesis box is ≤0.6 pages (if longer, move details to appendix)**
+- [ ] Appendix A has comprehensive literature review with detailed evidence
+- [ ] Appendix B has detailed experimental protocols
+- [ ] Appendix C has quality assessment tables
+- [ ] Appendix D has supplementary evidence
+- [ ] 10-15 citations in main text (selective)
+- [ ] 50+ total citations in full document
+- [ ] All boxes use correct colors
+- [ ] Document compiles without errors
+- [ ] References formatted correctly
+- [ ] **Compiled PDF checked visually for overflow issues**
+
+## Example Minimal Document
+
+```latex
+% !TEX program = xelatex
+\documentclass[11pt,letterpaper]{article}
+\usepackage{hypothesis_generation}
+\usepackage{natbib}
+
+\title{Role of X in Y}
+
+\begin{document}
+\maketitle
+
+\section*{Executive Summary}
+\begin{summarybox}[Executive Summary]
+Brief overview of phenomenon and hypotheses.
+\end{summarybox}
+
+\section{Competing Hypotheses}
+
+% Use \newpage before each hypothesis box to prevent overflow
+\newpage
+\subsection*{Hypothesis 1: Title}
+\begin{hypothesisbox1}[Hypothesis 1: Title]
+\textbf{Mechanistic Explanation:}
+Brief explanation in 1-2 paragraphs.
+
+\textbf{Key Supporting Evidence:}
+\begin{itemize}
+  \item Evidence point \citep{ref1}
+\end{itemize}
+\end{hypothesisbox1}
+
+\newpage
+\subsection*{Hypothesis 2: Title}
+\begin{hypothesisbox2}[Hypothesis 2: Title]
+\textbf{Mechanistic Explanation:}
+Brief explanation in 1-2 paragraphs.
+
+\textbf{Key Supporting Evidence:}
+\begin{itemize}
+  \item Evidence point \citep{ref2}
+\end{itemize}
+\end{hypothesisbox2}
+
+\section{Testable Predictions}
+
+\subsection*{Predictions from Hypothesis 1}
+\begin{predictionbox}[Predictions: Hypothesis 1]
+Predictions here.
+\end{predictionbox}
+
+\section{Critical Comparisons}
+
+\subsection*{H1 vs. H2}
+\begin{comparisonbox}[H1 vs. H2]
+Comparison here.
+\end{comparisonbox}
+
+% Force new page before appendices
+\appendix
+\newpage
+\appendixsection{Appendix A: Literature Review}
+Detailed literature review here.
+
+\newpage
+\bibliographystyle{plainnat}
+\bibliography{references}
+
+\end{document}
+```
+
+**Key Points:**
+- `\newpage` used before each hypothesis box to ensure they start on fresh pages
+- This prevents content overflow issues
+- Main text boxes kept concise (1-2 paragraphs + bullet points)
+- Detailed content goes to appendices
+
+## Additional Resources
+
+- See `hypothesis_report_template.tex` for complete annotated template
+- See `SKILL.md` for workflow and methodology guidance
+- See `references/hypothesis_quality_criteria.md` for evaluation framework
+- See `references/experimental_design_patterns.md` for design guidance
+- See treatment-plans skill for additional LaTeX styling examples
+