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skills/risk-of-bias/SKILL.md

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+---
+name: risk-of-bias
+description: "Assess risk of bias in research studies for systematic reviews. Use when: (1) Conducting systematic reviews, (2) Evaluating study quality, (3) GRADE assessments, (4) Meta-analysis planning."
+allowed-tools: Read, Write
+version: 1.0.0
+---
+
+# Risk of Bias Assessment Skill
+
+## Purpose
+Systematically evaluate methodological quality and potential biases in research studies.
+
+## Tools by Study Design
+
+**RCTs**: Cochrane Risk of Bias 2 (RoB 2)
+**Non-randomized**: ROBINS-I
+**Diagnostic Studies**: QUADAS-2
+**Prognostic Studies**: QUIPS
+
+## RoB 2 Domains
+
+1. **Randomization Process**
+   - Adequate sequence generation?
+   - Allocation concealment?
+
+2. **Deviations from Interventions**
+   - Blinding effective?
+   - Adherence to protocol?
+
+3. **Missing Outcome Data**
+   - Complete data?
+   - Appropriate handling?
+
+4. **Outcome Measurement**
+   - Blinded assessment?
+   - Validated measures?
+
+5. **Selective Reporting**
+   - All outcomes reported?
+   - Pre-registered?
+
+## Risk Levels
+
+- **Low**: Minimal bias
+- **Some concerns**: Potential bias
+- **High**: Serious bias likely
+
+## Integration
+
+Use with literature-reviewer agent for systematic quality assessment of included studies.
+
+---
+**Version:** 1.0.0