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name description allowed-tools version
risk-of-bias Assess risk of bias in research studies for systematic reviews. Use when: (1) Conducting systematic reviews, (2) Evaluating study quality, (3) GRADE assessments, (4) Meta-analysis planning. Read, Write 1.0.0

Risk of Bias Assessment Skill

Purpose

Systematically evaluate methodological quality and potential biases in research studies.

Tools by Study Design

RCTs: Cochrane Risk of Bias 2 (RoB 2) Non-randomized: ROBINS-I Diagnostic Studies: QUADAS-2 Prognostic Studies: QUIPS

RoB 2 Domains

  1. Randomization Process

    • Adequate sequence generation?
    • Allocation concealment?
  2. Deviations from Interventions

    • Blinding effective?
    • Adherence to protocol?
  3. Missing Outcome Data

    • Complete data?
    • Appropriate handling?
  4. Outcome Measurement

    • Blinded assessment?
    • Validated measures?
  5. Selective Reporting

    • All outcomes reported?
    • Pre-registered?

Risk Levels

  • Low: Minimal bias
  • Some concerns: Potential bias
  • High: Serious bias likely

Integration

Use with literature-reviewer agent for systematic quality assessment of included studies.


Version: 1.0.0