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skills/randomization/SKILL.md

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+---
+name: randomization
+description: "Implement proper randomization procedures for experiments. Use when: (1) Assigning participants to conditions, (2) Ensuring unbiased allocation, (3) Meeting CONSORT standards, (4) Pre-registration."
+allowed-tools: Read, Write, Bash
+version: 1.0.0
+---
+
+# Randomization Skill
+
+## Purpose
+Implement proper random assignment to minimize selection bias.
+
+## Randomization Methods
+
+**1. Simple Randomization**
+- Coin flip, random number generator
+- Best for large samples (N>200)
+- Risk of imbalance in small samples
+
+**2. Block Randomization**
+- Ensures equal group sizes
+- Blocks of 4, 6, or 8
+- Example: AABB, ABAB, BABA, BBAA
+
+**3. Stratified Randomization**
+- Balance prognostic factors
+- Stratify by sex, age group, severity
+- Then randomize within strata
+
+**4. Minimization**
+- Dynamic allocation
+- Minimizes imbalance across factors
+- Used in small trials
+
+## Implementation
+
+**Steps:**
+1. Generate random sequence (with seed)
+2. Document sequence generation
+3. Implement allocation concealment
+4. Execute randomization
+5. Document actual allocation
+
+**Example (Python):**
+```python
+import random
+random.seed(12345)  # Document seed
+sequence = ['A', 'B'] * 50  # 100 participants
+random.shuffle(sequence)
+```
+
+---
+**Version:** 1.0.0