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skills/experiment-design/SKILL.md

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+---
+name: experiment-design
+description: "Design rigorous experiments following best practices. Use when: (1) Planning research studies, (2) Grant proposal development, (3) Pre-registration, (4) Ensuring internal validity, (5) Meeting NIH rigor standards."
+allowed-tools: Read, Write
+version: 1.0.0
+---
+
+# Experiment Design Skill
+
+## Purpose
+Design methodologically rigorous experiments with appropriate controls and randomization.
+
+## Key Design Elements
+
+**1. Research Question**: Clear, testable hypothesis
+**2. Study Design**: RCT, quasi-experimental, observational
+**3. Sample Size**: Power analysis justified
+**4. Randomization**: Method specified
+**5. Blinding**: Who is blinded
+**6. Controls**: Appropriate comparison groups
+**7. Outcomes**: Primary and secondary clearly defined
+**8. Analysis Plan**: Pre-specified statistical approach
+
+## Common Designs
+
+**Between-Subjects**: Different participants per condition
+**Within-Subjects**: Same participants, repeated measures
+**Factorial**: Multiple factors (2x2, 2x3)
+**Crossover**: Participants receive all treatments
+**Stepped-Wedge**: Phased rollout
+
+## NIH Rigor Checklist
+
+- [ ] Scientific premise established
+- [ ] Rigorous design (appropriate controls)
+- [ ] Biological variables considered (SABV)
+- [ ] Authentication of key resources
+- [ ] Transparent reporting planned
+
+---
+**Version:** 1.0.0